星形胶质细胞对人脑神经细胞发育的影响

Effects of Astrocytes on Development of Human Fetal Brain Neuron

本实验建立了人胎大脑星形胶质细胞体外培养模型,应用星形胶质细胞适应性培养液培养12周龄人脑神经细胞。结果表明星形酸质细胞促进神经细胞突起的发育,提示星形胶质细胞是促进大脑神经细胞突起形态发育的主要调节因子之一,为进一步研究胶质细胞来源的神经营养因子提供了理想的实验手段。

The model of astrocyte culture from human fetal cerebrum was established.Theresult of neurites trophiceffect of neuron culture was obtained from human fetalbrain at 12 weeks of gestation using astrocytes conditioned medium.It is suggestedthat astrocyte product is one of the important neuro-trophic factors on morphologi-cal developmant in vitro.The model can be used in the research of neuro-trophicfactors from astrocytes.