60例胃镜采取胃粘膜病变的免疫组化改变

Immunohistochemical Changes of Endoscopic Gastric Mucosal Lesions in 60 Cases

用免疫组化方法对60例胃镜活检胃粘膜的标本进行分析,结果:19例慢性胃炎胃镜活检标本中胃泌素阳性率较高,生长抑素较低,CEA 缺如,12例慢性萎缩性胃炎中胃泌素与生长抑素阳性率相等,且均比慢性胃炎低,29例胃癌中,胃泌索及生长抑素均缺如,CEA100% 阳性,因此 CEA 染色在胃癌诊断中有较高价值。

Sixty cases of lesions of gastric mucosa included 19 cases of chronic superficial gastritis;12 cases of chronic atrophic gastritis and 29 cases of gastric carcinoma.All of 60 cases were studied immunohistochemically using 3 antibodies gastrin,soma-tostatin aod CEA.The chronic superficial gastritis showed strong positive reactionfor gastrin,slightly positive for somatostatin and negative reaction for CEA.Thechronic atrophic gastritis showed mild positive reaction for both gastrin and soma-tostain,but CEA negative reaction in 83% of the cases.All types of gastric carcinoma showed positive reactions for CEA.The resultsshowed that CEA was very useful in the diagnosis of the gastric carcinoma.