幼儿手背丘疹皮炎与病毒感染的实验研究

VIRUS INFECTION AND INFANTILE PAPULAR DERMATITIS OF DORSUM MANUS

对25名幼儿手背丘疹性皮炎患者的粪便和咽拭子标本进行病毒分离培养,结果获得肠道病毒4株,腺病毒1株,肠道病毒经鉴定为CoxsA_92株,ECHO_(25)1株。用所分离的病毒作成抗原对43名患者和40名健康者进行血清学对比研究。结果表明病毒感染和患者之间有明显相关性。同时对26名患者进行了双份血清学检测,结果显示CoxsA_9病毒组患者的血清抗体滴度大于4倍,阳性率达80.77％,而ECHO_(45)病毒和腺病毒组的血清抗体滴度均小于4倍,证明本组患者中CoxsA_9病毒感染与本病密切相关。

Four strains of enterovirus and one strain of adenovirus have been isolated from stool and pharyngeal swab by inocubation with primary human embryonic kidney cell culture in 25 cases of infantile papular dermatitis of dorsum manus. Two strains of Coxsackie A-9 virus and one strain of Echovirus-25 were identified. With the isolated virus as antigen, a matched pair study of the sera antibody test was carried out in 43 children with papular dermatitis and in 40 normal individuals as control. In 26 cases of Coxsackie A-9 virus positive papular dermatitis, a 4-fold rise (>1:16) of the relative serum antibody has been observed in80.77%), while none of this high level was observed in patients with Echovirus-25 and adenovirus dermatitis (<1:16). It would be reasonably to conclude that epidemic Coxsackie A-9 virus infection was obviously related to infantile papular dermatitis and probably the main cause of the disease.