恶性纤维组织细胞瘤免疫标记的研究

Immunohistochemical Investigation on Malignant Fibrous Histiocytoma

用口α_1-抗糜蛋白酶(α_1-ACT)抗血清检测了70例肉瘤、9例癌和5例恶性黑色素瘤。70例各种肉瘤中31例呈阳性反应,其中25例恶性纤维组织细胞瘤中17例呈阳性反应,5例恶性黑色素瘤均呈阳性反应,9例癌均呈阴性。研究结果说明仅用 ACT 在鉴别各种肉瘤上价值不大,也不能做为组织细胞特异性标记物。并指出合理选择,配套使用特异性抗血清是确定肿瘤诊断的关键。

A polyclonal commercially available antiserum to alpha-1-antichymotrypsin(α_1-ACT)was used to label 70 sarcomas,9 carcinomas,5 malignant melanomas.In 31 ofthe 70 sarcomas,including 17 of 25 malignant fibrous hlstiocytomas and 5 malignantmelanomas the tests were positive.In 9 careinomas they were negative.The resultssuggested that the use of α_1-ACT only was of little valve in the differential diagno-sis of sarcomas,nor could it be used as a specific histiocytic marker.The successof using immunohistochemistry for making pathologic diagnosis depends upon rationalapplication of panel of antisera.