单诺沙星对大肠杆菌和金葡球菌的体外抗菌后效应

Studies on Postantibiotic Effects of Danofloxacin in Vitro against E. coli and S. aureus

采用菌落计数法测定了单诺沙星在三种不同浓度下对大肠杆菌和金黄色葡萄球菌 (金葡球菌 )的体外抗菌后效应 (PAE)。当药物浓度为 0 .5MIC、2MIC、4MIC时 ,对大肠杆菌的PAE值为 (0 .6 4 6 4± 0 .0 2 94 )h、(1.2 0 77± 0 .0 2 84 )h、(1.6 5 2 9± 0 .0 4 96 )h ;对金葡球菌的PAE值为 (0 .5 6 6 0± 0 .0 0 75 )h、(1.174 6± 0 .0 0 5 7)h、(1.4 913± 0 .0 2 5 7)h。这表明单诺沙星对大肠杆菌、金葡球菌均有不同程度的较强的PAE 。

The postantibiotic effects (PAE) of danofloxacin in vitro at three different concentration levels against E. coli and S.aureus were tested by routine colonial counting method.When the concertations of danofloxacin were 0.5MIC?2MIC and 4MIC, the PAE of E.coli were (0.6464±0.0294) h?(1.2077±0.0284) h?(1.6529±0.0496) h;the PAE of S.aureus were (0 5660±0.0075) h ?(1.1746±0.0057) h?(1 4913±0.0257) h . This showed that the PAE of danofloxacin against E.coli and S.aureus was very strong . And the PAE will be higher when the concertations were increased.