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膀胱癌尿脱落细胞CK20表达的临床意义 被引量:8

Expression of cytokeratin 20 in exfoliated urothelial cells of bladder cancer
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摘要 目的 探讨尿脱落细胞CK2 0表达在膀胱癌诊断中的意义。 方法 应用免疫组化技术检测 4 0例膀胱癌患者和 2 0例非肿瘤患者尿脱落细胞CK2 0的表达。 结果 非肿瘤组尿脱落细胞无CK2 0表达 ,肿瘤组尿脱落细胞CK2 0表达率为 5 3% ,CK2 0与HE染色结合检测 ,阳性率达90 %。复发组尿脱落细胞CK2 0表达率 80 % ,明显高于初发组的 4 3% (P <0 .0 5 )。CK2 0表达率与肿瘤分级、分期无相关性。 结论 尿脱落细胞CK2 0表达检测特异性高 。 Objective To study the expression of cytokeratin(CK)20 in exfoliated urothelial cells and to evaluate its clinical significance. Methods The expression of CK20 in exfoliated urothelial cells in 40 patients with bladder cancer and 20 subjects with normal urothelium was observed with immunohistochemical methods. Results The positive staining of CK20 in patients with bladder cancer was 52.5%, the expression of CK20 was negative in all controls, the positive rate of expression of CK20 combining with HE staining in patients with bladder cancer was 90%. The expression of CK20 was significantly higher in recurrent cases(80%) than in primary cases(43.3%). CK20 was not related to the tumor grade or stage. Conclusions The results suggested that the method had a higher specificity and therefore CK20 would be a good diagnostic marker.
出处 《中华泌尿外科杂志》 CAS CSCD 北大核心 2002年第4期215-217,共3页 Chinese Journal of Urology
关键词 膀胱癌 尿脱落细胞 CK20 临床意义 细胞角蛋白 诊断 免疫组织化学 Bladder neoplasms Carcinoma Cytokeratin
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  • 1Moll R,Lowe A,Laufer J,et al.Cytokeratin 20 in human carcinomas-a new histodiagnositic marker.Am J Pathol,1992,140:427- 447.
  • 2刘冉.细胞角蛋白20及其在肿瘤诊断中的应用[J].国外医学(肿瘤学分册),1998,25(1):14-16. 被引量:4
  • 3Harnden P,Eardley I,Joyce A.D,et al.Cytokeratin 20 as an objective marker of urothelial dysplasia.Br J Urol,1996,78:870-875.
  • 4Klein A,Zemer R,Buchumensky V,et al.Expression of cytokeratin 20 in urinary cytology of patients with bladder carcinoma.Am Cancer,1998,82:349-354.
  • 5Harnden P,Mahmood N,Southgate J.Expression of cytokeratin 20 redefines urothelial papillomas of the bladder.Lancet ,1999,353:9157.

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  • 1吴小候,蒲军,刘彦慧,唐敏,罗春丽.快速检测尿液CK20方法的建立[J].重庆医学,2007,36(14):1355-1356. 被引量:1
  • 2Walsh MD, Hohn BG, Thong W, et al. Mucins expression by transitional cell carcinomas of the bladder[J]. Br J Urol, 1994,73:256- 262.
  • 3Dreller MJ. Bladder Cancer. State of the art cancer [ J ]. CA Cancer J Clin. 1998,48(5) :269-284.
  • 4Grossman HB. New methods for detection of blader cancer[j].Semin Urol Oncol, 1998,16( 1 ):17-22.
  • 5Ramakumar S, Bhniyan J, Besse JA, et al. Comparison of Screening methods in the detection of bladder cancer[J]. J Urol,1999,161 (2) :388-394.
  • 6Brown FM. Urine cytology: it is still the gold standard for screening[J]. Urol Clin North Am, 2000,27:25-37.
  • 7Lesuffeur T, Z Welbanm A, Real FX. Mucins in normal and neoplastic human gastrointestinal tissues[J]. Grit Rev Oncel Hernatol; 1994,17:153-180.
  • 8Hansk L, Hofmeier M, Schmitt-Graff A, et al. Over Expression or ectopic expression of Muc2 is the common property of mncinous carcinomas of the colon, pancreas, breast, and ovary[J]. J Pathol, 1997,182:385-391.
  • 9Huben RP. Tumor markers in bladder cancer[J]. Urolgy, 1984,23(3) :10-14.
  • 10Retz M, Lehmann JE. Muein7 and eytokeratin 20 as new diagnostic urinary markers for bladder tumor[ J]. J Urol, 2003,169:86-89.

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