体外冲击波碎石后结石高复发原因的实验研究

Causes of recurrence of urinary calculi following ESWL

目的 探讨上尿路结石体外冲击波碎石 (ESWL)术后结石高复发的原因。 方法 构建羊肾盂结石动物模型 ,对模型动物行ESWL ,分期观察羊肾并行组织形态学检查。 结果 碎石后1周肾盂粘膜均有不同程度的损伤 ,粘膜内有结石微小颗粒嵌入 ,肾小盏内有弥散的小结石颗粒嵌入 ;2周后肾盂粘膜开始修复 ,4周基本恢复正常 ,但粘膜内嵌入的微小结石仍然存在 ,且周围出现纤维化包裹。 结论 ESWL术后结石复发与碎石所产生的微小颗粒粘膜嵌入肾盏及粘膜损伤有关。

Objective To investigate the causes of urinary calculi recurrence following ESWL. Methods After constructing the animal model of urinary calculi,the sheep with stone were treated by ESWL and the treated kidney was checked with morphological studies. Results The renal pelvic membrane was initially damaged heavily,the injure being healed from 2 ～ 4 weeks.At the same time, there were some calculi particles embeded in the renal pelvic membrane. Conclusions The embeded calculi particles and the damage of the pelvic membrane were the main causes of calculi recurrence following ESWL.