联合化疗并脐血输注治疗复发性难治性急性白血病疗效观察

The Observation of the Efficacy of the Combinative Chemotherapy with Transfusing Cord Blood for Treatment of Repeated and Refractory Acute Leukemia

目的 观察脐血和成人静脉血输注对难治性急性白血病的辅助疗效和副作用。方法 将急性白血病患者分为 A、B(ANL L )和 A′、B′(AL L )共 4组 ,其中 ANL L的 A、B两组及 AL L的 A′、B′两组分别采用各自两组化疗方案 ,但 A、A′组采用脐血输注 ,B、B′组则采用成人静脉血输注。结果 A、A′组和 B、B′组疗效相近 ,但预后不同。脐血输注组院内感染率低 ,血象恢复快 ,死亡率低 ,且输血副作用小。

Objective To observe the assistant effects and side effects when using transfusing cord blood and transfusing adult vein blood for the treatment to refractory acute leukemia.Methods Patients with acute leukemia were divided into four groups:A?B for ANLL and A′?B′for ALL?The respective chemotherapy for ANLL and ALL was carried out with cord blood being transfused in A and A' and the adult vein blood in B an d B′.Results The efficacies were similar in A?A′ and B?B′,but the prognoses were different.A?A′ groups had lower occurrence of hospital infection, faster renewer in blood components, lower death rate and fewer side effects than B?B′ groups.Conclusions Transfusing cord blood in combination with chemotherapy was better than transfusing adult vein blood assisted chemotherapy in treatment to refractory acute leukemia.