尿视黄醇结合蛋白在糖尿病肾病早期的诊断意义

The Singnificanoe Of Urinary Retinal Binding Protein(RBP) As a Marker In The Early Diabetic Nephropathy

目的 探讨尿视黄醇结合蛋白(RBP)在糖尿病肾病早期的诊断意义。方法 采用酶联免疫法(ELISA)测定78例非胰岛素依赖型糖尿病(NIDDM)患者和30例健康人的尿RBP,同时测定尿微量白蛋白(Alb)和尿β_2-微球蛋白(β_2-MG)。结果 NIDDM患者RBP较正常对照组增高,尿RBP与尿Alb、尿β_2-MG呈正相关。结论 尿RBP可作为诊断早期糖尿病肾病的敏感指标。

Object To study the significance of urinary retinal binding protein(RBP) as a markering the early diabetic nephropathy. Methods The concentration of RBP in the urine of 78 cases with NIDDM and 30 normal subjects was measured by ELISA. The concentration of Albumin (Alb) and beta2-microgLobulin(β2-MG) in the urine also measured. Results The urine RBP in all three groups was significantly higher than that in control group. The urine RBP related positively to urine Alb andβ2 MG. Conclusions The urine RBP is an indicator of the diagnosis of the early diabetic nephropathy.