Egr-1基因的辐射生物学效应研究进展

Advances in the Research of the Role of Egr-1 Gene in cells' Respo nse to Ionizing Radiation

Egr- 1(Earlygrowthresponse - 1)基因是一系列“立即早期基因 (Immediateearlygene)”中的重要一个 ,参与细胞的多种辐射生物效应。研究表明 ,Egr- 1在多种正常细胞和肿瘤细胞受到电离辐射后的早期就能被激活 ,它的激活表达与辐照后细胞的生长、周期、凋亡等的改变密切相关。另外 ,Egr - 1基因调控序列具有辐射可诱导特性 ,这一特点使其有了潜在的临床和基因工程生产应用前景。

Egr-1(Early Growth Response-1)gene is an improtant member of the 'Immediate Early Growth'gene family,participating in multiple radiation biological effects of the irradiated cells.Studies have shown that after ionizing radiation,Egr-1 gene can be activated at an early stage in many types of tumor and normal cells.Its acitivation and the consequent expression is believed to have a close relation to the change in cell growth,cell cycle and apoptosis of the irradiated cells.Additionally,the radiation-inducible property of the Egr-1 gene regulating sequence confers potential clinical and genetic engineering sues.