血液粘度与心输出量的相关性及临床应用研究

Study on correlation between blood viscosity and cardiac output and its clinical application

目的 本文旨在阐明血液粘度与心输出量之间存在着规律性的联系。方法 在 40例正常人及 2 0 0例心脏病患者中 ,以锥板法测定不同切变率下的全血粘度 (ηb)和血浆粘度 (ηp) ,以二维超声心动图按改良Simpsom氏法测定心输出量 (CO) ,所得数据进行直线相关回归分析。结果 CO与 ηb、ηp均呈显著负相关。进一步将病例分组对照 ,以比较降低血粘度 (甲组 )和扩张阻力血管 (乙组 )两者对CO的影响 :甲组静滴低分子右旋糖酐 30 0毫升加蝮蛇抗栓酶 1.5u和口服抵克力得 (Ticlid ) 5 0 0mg,每天一次 ,用药两周 ;乙组静滴酚妥拉明 (Regitime) 2 0mg,每天一次 ,用药两周。两组病例各在用药前及停药后 1- 5周每周测定一次CO ,5次的CO均数作为该组治疗后的平均心输出量水平。经对照检验 :甲组在提高心输出量水平上有更显著的作用。结论 血液粘度是影响心输出量比较稳定的因素 ,降粘治疗对增加心输出量是为有效、平稳、持久的疗法。

Objective To expound the correlation between blood viscosity and cardiac output.Methods 200 patients with cardiopathy and 40 healthy control subjects were included. Blood viscosity(ηb) and plasma viscosity(ηρ) were determined in variant shear rate by Weissenberg's method. Cardiac output(CO) was measured with two-dimensional echocardiogram by reform Simpson's method. All data were analysed with linear correlation regression.Results Cardiac output was negative correlated with blood viscosity(ηb) and plasma viscosity(ηρ). The cardiac output improved significantly in group A than in group B.Conclusion Blood viscosity influences steadily on cardiac output.Blood viscosity is an effective, stable, lasting therapy on improving cardiac output.