粘质沙雷氏菌苗治疗56例恶性胸腔积液

Curative effect of Serratia marcescens vaccine in treatment of malignant pleural effusion

目的 :观察生物反应调节剂粘质沙雷氏菌苗治疗恶性胸腔积液的疗效。方法 :5 6例恶性胸水患者为菌苗组 ,胸水引流后 ,注入粘质沙雷氏菌苗。另取病情相当的 32例恶性胸水患者 ,作为对照组 ,注入 5 氟尿嘧啶及顺铂。结果 :治疗组有效率 94 .6 % ,平均起效时间 9.7天。对照组有效率 78.1% ,平均起效时间 17.2天 ,两者差异有显著统计学意义。治疗组主要毒副反应为发热及胸痛 ,无其他严重毒副反应。结论 :粘质沙雷氏菌苗能有效控制恶性胸水 ,起效快 ,毒副反应小 ,患者生存质量提高 。

Purpose:To evaluate the therapeutic effect of serratia marcescens vaccine(S 311 ) in treatment of malignant pleural effusion. Methods:56 patients with malignant pleural effusion were treated with serratia marcescens vaccine, another 32 cases were treated with DDP and 5 FU as control. Results:Response rates were 94.6% and 78.1%. Average effectual times were 9.7and 17.2 days. Statistical difference was noted between these two groups. The toxicities in group SMV were fever and thoracalgia .No other serious side reactions occurred in group S 311 . Conclusions:The therapy with S 311 can effectively control the malignant pleural effusion. The effect was quick. The side effect was light and this treatment can improve the life quality of patients. Therefore, it is warranted for wide use.