单纯性肾病综合征患儿血、尿sIL-2R水平及其相关性

Correlation of serum and urinary sIL-2R levels in children with simple nephrotic syndrome

目的 检测单纯性肾病综合征 (SNS)患儿血、尿可溶性白介素 2受体 (sIL 2R)水平 ,分析其相关性。 方法 采用ELISA法对 38例SNS患儿极期和恢复期血清、尿sIL 2R进行检测 ,并与正常组进行比较。用直线相关分析血、尿sIL 2R水平间的相关性。 结果 SNS患儿极期血清和尿sIL 2R水平与正常组比较均显著增高 (q =2 4 .32 2、33.0 2 3,P均 <0 .0 1) ;缓解期与极期比较均显著下降 (q =2 3.4 72、33.90 1,P均 <0 .0 1) ,但与正常组比较仍在较高水平 (q =9.0 74、4 .0 73,P均 <0 .0 1)。极期与缓解期血清sIL - 2R水平和尿sIL - 2R水平呈显著正相关 (r =0 .937,P <0 .0 1)。 结论 SNS患儿血、尿sIL 2R水平均增高 ,两者显著相关 ,故可通过检测尿sIL 2R水平 (代替血清sIL 2R检测 )反映SNS病情变化。

Objective To detect the levels of serum and urinary soluble interleukin 2 receptor (sIL 2R) in children with simple nephrotic syndrome (SNS),and to analyse their correlation. Methods The levels of serum and urinary sIL 2R in acute and recovery phases of SNS group were measured by ELISA method and compared to those of normal group. The correlation of serum and urinary sIL 2R levels was determined with linear correlation. Results The levels of serum and urinary sIL 2R in acute phase of SNS group were significantly increased than those in normal group (q=24.322 and 33.023, respectively,P all <0.01), and obviously decreased in recovery phase (q=23.472 and 33.901,respectively, P all <0.01). The levels of serum and urinary sIL 2R in recovery phase of SNS group were significantly higher than those of normal group (q=9.074 and 4.073, respectively,Pall <0.01). The level of urinary sIL 2R was significantly correlated to the level of serum sIL 2R(r= 0.937 ,P<0.01). Conclusion The levels of serum and urinary sIL 2R were increased in SNS, and there is a positive correlation between them. Therefore,to detect the level of urinary sIL 2R (repeat the level of serum sIL 2R) can draw the changes of the condition of patients with SNS.