补肾、健脾及脾肾双补对地塞米松诱发之骨质疏松大鼠PTH、CT、T、E_2及BGP值影响的实验研究

The Experiment Study of Effect on PTH CT T E_2and BGP by Chinese HerbBushen Jianpi and Pishenshuangbu to Osteoporosis Rats Established by Dexamethasone

目的 :探讨补肾、健脾及补肾合健脾三种中药防治由地塞米松诱发之大鼠骨质疏松的效果及作用机制 ,为临床用药及进一步有效筛选中药提供依据。方法 :采用 12月龄的老年 SD大鼠 ,随机分为 5组 ,给予地塞米松造模。于中药治疗后 6w和 13 w测定骨密度、血清降钙素、骨钙素、性激素及甲状旁腺素。结果 :三种方药均可有效地改善骨质疏松症状。补肾中药以增高性激素浓度尤其是血清睾酮为主 ,健脾则通过降低甲状旁腺素 ( PTH)来抑制骨的吸收 ,而补肾和健脾则可协同提高血清降钙素 ( CT)的浓度。结论 :补肾。

Objective:To study the efficacy and mechanism of Chinese Herb BGuShen JianPi and PiShuangBu to osteoporosis rats established by Dexamethasone(DM).Methods:Fifty male Sprague-Dawley rats at the age of 12 month being divided into five groups and being administered appropriately by DM and Chinese Herbs.Results:All three therapy could improve the symptom of osteoporosis effectively.BuShen herb could increase sex hormone chroma in serum even T.JianPi herb could inhibit bone absorbing by decreasing PTH in serum and PiShenShuangBu could increase CT chroma in serum cooperatively.Conclusion:Both BuShen JinaPi and Pi ShneShuangBu could prevent and treat osteoporosis from different link.