摘要
目的 :探讨玫瑰花水煎剂对去甲肾上腺素预收缩离体兔主动脉平滑肌张力的影响及其机制。方法 :制备离体兔胸主动脉平滑肌条 ,固定于灌流肌槽中 ,记录肌条张力变化。结果 :酸性和中性玫瑰花水煎剂均可明显扩张去甲肾上腺素预收缩主动脉平滑肌条 ,此作用与 10 5mol/LAch相似。去除内皮细胞、10 4 mol/LL NNA或 10 5mol/L亚甲兰可完全消除玫瑰花舒张血管作用 ,但 10 5mol/L吲哚美辛和普萘洛尔无明显影响。结论 :玫瑰花水煎剂可使血管平滑肌扩张 ,此作用有内皮依赖性 ,与NO有关。
Objective: To observe the effect of Flos Rosae (FRR) on isolated rabbit aorta precontracted with 10 -6 mol/L NA. Methods: Isolated rabbit aortic muscle strips were used to perfuse in chambers and record their tensions. Results: Similar to 10 -5 mol/L Ach, 20g/L acid or neutral water decoction of FRR significantly relaxed isolated aorta precontracted with 10 -6 mol/L NA. The relaxant effect of FRR completely disappeared after removal of vascular endothelium or preincubation with inhibitors of nitric oxide synthase (L-NNA) or guanylate cyclase (mehtylene blue) respectively, but did not effect by prostaglandin synthase inhibitor or blockage of adrenergic β receptor. Conclusion: FRR can relax isolated rabbit aorta, which may be endothelium-dependent and is relate to NO.
出处
《中药药理与临床》
CAS
CSCD
2002年第2期20-21,共2页
Pharmacology and Clinics of Chinese Materia Medica
基金
甘肃省科委中青年基金资助项目 (WS991 A2 3 0 1 1 )
