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盐酸氯丙嗪注射液的稳定性预测 被引量:2

Estimation of Stability of Chlorpromazine Hydrochloride Injection
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摘要 目的:预测盐酸氯丙嗪注射液稳定性,为临床提供贮存期依据。方法:采用紫外分光光度法测定其含量,用经典恒温法预测其有效期。结果:本品稳定性与温度有关,符合Arrhenius公式,但对日光不稳定。结论:本品不稳定,应制定有效期,并注意在避光条件下贮存。 Objective: To estimate the stability of chlorpromazine hydrochloride injection, which would provide the base of storage life for clinic. Method: The content of chlorpromazine hydrochloride injection was determined by UV-spectrophotometry, the storage life was determined by the method of classic constant temperature. Result: The stability of chlorpromazine hydrochloride injection was associated with the temperature, which was in consistence with Arrhenius equation, being unstable under the sunshine. Concluson: chlorpromazine hydrochloride injection is unstable, the storage life should be established, and it should be protected from light.
作者 郭洪寅
出处 《中国药师》 CAS 2002年第5期270-272,共3页 China Pharmacist
关键词 氯丙嗪 稳定性 有效期 分光光度法 盐酸氯丙嗪注射液 抗精神病药 Chbrpromazine hydrochloride injection Stability Storage life UV-Spectrophotometry
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参考文献2

  • 1-.中华人民共和国药典(二部)[M].北京:化学工业出版社,2000.353.
  • 2庞贻辉 鲁纯素.药物稳定性预测方法[M].北京:人民卫生出版社,1984.35-36.

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