不同鼠种全血卡森值的测定分析

A TEST AND ANALYSIS OF THE COSSON VALUES IN THE WHOLE BLOOD OF DIFFERENT RATS

目的:了解裸鼠、金黄地鼠及SD大鼠血液流变学参数正常值。方法:采用锥板式粘度计对裸鼠、金黄地鼠、SD大鼠全血粘度进行同步检测,并采用线性回归的方法求出各组Casson粘度(CV)及Casson(CY)屈服值。结果:三种鼠高切粘度、红细胞压积,红细胞刚性指数检测值相近,裸鼠组检测值略高,但差异无统计学意义(p>0.05);低切粘度、红细胞聚集指数、血浆粘度有较明显差异(p<0.01),大鼠值最高,统计学分析差异具显著意义。三种鼠Casson粘度无明显差异(p>0.05),而Casson屈服应力有显著差异(p<0.01)。结论:结果提示三种动物红细胞变形能力基本相似,但涉及多种细胞外因素的红细胞聚集性,三种动物间则存在明显差异。

To observe the normal hemorheological characteristics of the nude mice,hamsters and Sprague-Dawley(SD)rats.Methods:The blood viscosity values of the nude mice,hamsters and SD rats were tested simultaneously by means of the cone and plate viscometer and Cosson Viscosity(CV),Cosson yield stress(CY)in the blood among them were obtained by unitary linearly regression.Results:The whole blood viscosity at high shear rate,hemot-ocrit,erythrocyte index of rigidity among three animals were nearly the same,there was a little higher in the nude rat group and no statistically significant difference among three groups.Significant difference existed in the values of whole blood viscosity at low shear rate,plasma viscosity and aggregation index of erythrocyte(p<0.01).The values of the SD rats were the highest among three groups.In the CV value there was no statistically sig-nificant difference among three groups(P>0.05).Significant difference was found in the CY value(p<0.01).Con-clusion:The erythrocyte deformability properties is nearly the same among the three animals.But in the charac-ter of the erythrocyte aggregation which involved many other factors outside the blood cells,there existed signifi-cant difference among the three animals.