摘要
为研究治糖保肾冲剂对早期糖尿病肾病 (DN)的作用机理。 30只大鼠用链脲佐菌素及福氏佐剂诱发糖尿病肾病模型 ,并随机分为模型组、中药组 (治糖保肾冲剂 )、西药组 (洛丁新 ) ,分别予相应药物治疗 ,另取 10只同种鼠为正常对照组。 4周后检测血浆ET、NO含量。结果 :中药组治疗后尿微量白蛋白 (UAIb)、血浆ET和NO水平均明显低于模型组 ,NO低于西药组 ,P <0 0 5。提示治糖保肾冲剂治疗早期DN的机理与调整ET。
To investigate the mechanism of “Zhitang Baoshen Granule”in the treatment of early diabetic nephropathy(DN),30 rats were established to be diabetic nephropathy by streptozotocin and fortimicin and were then randomized into three groups:model group(n=10),Chinese medicine group(n=10)treated with“Zhitang Baoshen Granule”and western medicine group(n=10) treated with Lotensin.Another 10 rats were treated with no medicine as control group.After 4 week treatment,the plasm ET and mitric oxide(NO)were measured.Results:After treatment the contents of UAlb,ET and NO in Chinese medicine group were less than those in model group;the content of NO in Chinese medicine group than in western medicine, P <0 05.It is revealed that “Zhitang Baoshen Granule”can regulate the contents of ET and NO in the treatment of early diabetic nephropathy.
出处
《上海中医药杂志》
北大核心
2002年第4期27-29,共3页
Shanghai Journal of Traditional Chinese Medicine
