帕罗西丁治疗消化性溃疡的临床研究

Clinical study of Paroxetine for treatment of peptic ulcer

目的 探讨精神、心理因素在消化性溃疡中的地位及帕罗西丁对消化性溃疡的治疗作用。方法 将我院 5 2例 ,汉密顿抑郁量表 (HAMD)评分 >2 0分 ,汉密顿焦虑量表 (HAMA)评分 >14分的消化性溃疡患者随机分为两组 :帕罗西丁组 2 6例 ,帕罗西丁 10～ 2 0mg,每日晨服 ,雷尼替丁 15 0mg ,2次 d;对照组 2 6例 ,口服雷尼替丁15 0mg ,2次 d。两组疗程均为 4周。 结果 帕罗西丁组溃疡愈合率为 88 5 % ,对照组为 5 7 7% ,差异有显著性意义 (P <0 0 5 ) ;帕罗西丁组治疗 4周后抑郁、焦虑等躯体和精神症状评分结果与治疗前的比较 ,差异有非常显著性意义(P <0 0 0 1)。结论 精神、心理因素对消化性溃疡的发生发展起着重要作用 ,帕罗西丁对其疗效确切。

Objective To study clinical treatment of Paroxetine for peptic ulcer.Methods 52 patients with peptic ulcer were randomly divided into two group,the treatment group and the control group( Hamilton Depression Scale ≥20 scores,Hamilton Anxiety Scale ≥ 14 scores).The patients in treatment group took 10～20 mg Paroxetine in the morning and 150 mg Ranitidine twice a day.The patients in control group only took 150 mg Ranitidine twice a day.Results The healing rate in treatment group (88 5%) was higher than that in control group(57 7%)( P <0 05).After 4 weeks of treatment,the anxiety and depression of patients in treatment group decreased greatly.( P < 001).Conclusion Psychological factors play an important part in treatment for peptic ulcer.Paroxetine is also effective in treating peptic ulcer.