血小板减少性紫癜患儿巨细胞病毒感染的研究

STUDY THE IDIOPATHIC THROMBOCYTOPENIC PATIENTS WITH HCMV INFECTION

研究人类巨细胞病毒 (HCMV)感染与原发性血小板减少性紫癜 (ITP)之间的关系 ,采用ACD抗凝外周血HCMV DNAPCR以及非抗凝血清CMV IgM、IgGELISA方法 ,进行HCMV感染的检测。结果显示 ,ITP患儿组HCMV DNAPCR阳性率为71 7% ,体检儿童对照组为 2 0 8% ,P <0 0 1 ,差异有显著性。ITP患儿组CMV IgM阳性率为 4 1 5% ,CMV IgG阳性率为 75 5% ,体检儿童对照组中未检出CMV IgM阳性者 ,CMV IgG阳性率为 2 2 9% ,P <0 0 1差异有显著性。结论认为 :HCMV感染与ITP密切相关 ,HCMV病毒是ITP致病病因中很重要的一个致病病毒 ,对ITP患者的实验室检测不仅需要血液学检测而且需要HCMV等病毒学检测 ,对HCMV活动性感染的ITP患者加用更昔洛韦 ,可能会很好地提高疗效。

To study the relationship between Human cytomegalovirus(HCMV) and idiopathic thrombocytopenic purpura(ITP), we detected the HCMV infection for 53 patients with ITP and 48 children with normal control by ploymerase chain reaction(PCR) and ELISA. 38 of 53 the patients and 10 of 48 normal controls were positive for HCMV DNA by PCR. 22 patients were positive for CMV IgM and 40 patients were positive for CMV IgG by ELISA. Only 11 of all normal controls were positive for CMV IgG by ELISA.The conclusion is that there are relation between HCMV infection and ITP. So Ganciclovir may be useful to improve the clinical effects of ITP patients with active HCMV infection.