摘要
目的探讨乙型肝炎病毒(HBV)与其它型肝炎病毒重叠感染对血清中乙型肝炎病毒标志物的影响。方法采用酶联免疫吸附试验(ELISA)方法,检测了HBV感染者血清中各型肝炎病毒抗体和HBV标志物,选取其中已确诊为重叠感染者49例作为实验组,并从已确诊为单一HBV感染者中随机抽取68例作为对照组。结果重叠感染组血清HBsAg、抗-HBcIgG、抗-HBcIgM等阳性率均明显低于对照组(P<0.05),而抗-HBs阳性率则明显高于对照组(P<0.05)。其中丙型或戊型肝炎与HBV重叠感染时,HBeAg阳性率明显低于对照组(P<0.05)。结论其它型肝炎病毒与HBV重叠感染后,病毒间存在相互干扰作用,丙型及戊型肝炎病毒与HBV重叠感染时在一定程度上可抑制HBV复制。
Objective To study the influence of superinfection with HBV and oth-er hepatitis virus on the HBV immunological markers.Methods Using ELISA(Enzyme-linked immunosorbent assay)to detect antibodies of various hepatitis viruses and HBV markers in the srea of patients,chose49with HBV infection,patients confirmed to be with superinfection as the experimental group and68patients with HBV only as the control group.Results The positive rates of HBsAg,anti-HBc-IgG,anti-HBc-IgM in srea of the experimental group were significantly lower than those in the control group(P<0.05),but the anti-HBs postive rate was higher(P<0.05),and when HBV coexisting with HCV or HEV,the HBeAg positive rate was lower (P<0.05).Conclusion HBV replications are inhibited on a certain degree when HBV is superinfected by other hep-atitis viruses.
出处
《江西医学检验》
2002年第2期77-78,共2页
Jiangxi Journal of Medical Laboratory Sciences
