乳房乳头部腺瘤15例临床病理分析

Adenoma of the nipple: a clinicopathological analysis of 15 cases

目的 研究乳房乳头部腺瘤的形态学特点 ,探讨其诊断及鉴别诊断。方法 对我院 1 991— 2 0 0 0年间 1 5例乳头部腺瘤进行临床病理分析。结果 乳头部腺瘤好发于中年女性 ,多数患者伴乳头溢液 ,镜下导管上皮细胞增生 ,以乳头状或腺瘤样增生为主 ,外周肌上皮细胞免疫标记 ,如SMA、S 1 0 0对肌上皮辨别有帮助。结论 乳头部腺瘤是一种少见的乳腺良性肿瘤 ,认识其临床及病理形态特点 ,对湿疹样癌、导管内乳头状瘤。

Objective To study the morphological characteristics of adenoma of the nipple with an emphasis on differential diagnosis. Methods Clinical and pathological features were analyzed in 15 cases of adenoma of the nipple. Results Adenoma of the nipple occurred predominantly in the middle aged women. Clinically, most patients complained of nipple discharge,. Histologically, the tumor was composed of adenomatoid or papillary proliferation of ductal cells surrounded by a compact layer of myoepithelial cells. Immunostaining for SMA and S 100 was helpful in identification of the myoepithelium. Conclusions Adenoma of the nipple is a rare benign tumor. Recognizing its clinical and pathological characteristics is important to avoid the misdiagnosis as Paget's disease, intraductal papilloma, syringomatous adenoma of the nipple and invasive ductal carcinoma.