E-钙黏附素和CD44v6在舌癌中的表达及其意义

Expression and significance of E-cadherin and CD44v6 in carcinoma of the tongue

目的 探讨舌癌中E 钙黏附素、CD44v6的表达特征及临床意义。方法 取我院经病理证实初诊舌癌患者 45例。采用S P法免疫组化染色检测舌癌中E 钙黏附素和CD44v6。结果 CD44v6和E 钙黏附素总的阳性率为71 1 %和 64 4%。E 钙黏附素在高分化鳞癌中的阳性表达率均显著高于中低分化鳞癌 (P <0 0 5)。CD44v6在高分化鳞癌中的阳性表达率与中低分化鳞癌无差异 (P >0 0 5) ,有转移者E 钙黏附素阳性表达率显著低于无转移者(P <0 0 5) ,而CD44v6阳性表达率显著高于无转移者 (P <0 0 5) ,局部肿瘤T1 2 与T3 4 之间二项指标无统计学意义(P >0 0 5)。E 钙黏附素阳性表达率在临床Ⅲ、Ⅳ期的病例中比Ⅰ、Ⅱ期显著降低 (P <0 0 5)。CD44v6阳性表达率在临床Ⅲ、Ⅳ期的病例中比Ⅰ、Ⅱ期显著升高 (P <0 0 5)。结论 E 钙黏附素和CD44v6与舌癌病理分级、转移、预后密切相关 ,而与肿瘤大小无明显相关性 ,且该两项指标表达方式相反。当E 钙黏附素阴性、CD44v6阳性时 。

Objective To study the expression of E cadherin and CD44v6 in tongue carcinoma. Methods Pathological diagnosis was made in 45 cases of tongue carcinoma. Immunohistochemical staining for E cadherin and CD44v6 was performed using S P method and paraffin-embedded tissues in all the cases. Results Positive rates of the expression of E cadherin and CD44v6 were 71.1% and 64.4% respectively. Expression of E cadherin in well differentiated carcinoma is higher than that in poor differentiated one (P<0.05), and there was no difference of CD44v6 expression between the two groups. And expression of E cadherin in the cases with cervical lymph node metastasis was significantly higher than that without the metastasis (P<0.05) , but vice versa in the expression of CDv6. There was no difference in E cadherin and CD44v6 expression between the localized tumors of T 1-2 and T 3-4 . Expression of E cadherin in the stage III and stage IV was lower than that in stage I and stage II of the cancer (P<0.05). Conclusions Expression of E cadherin and CD44v6 is closely related to the tumor grading, metastasis and prognosis in tongue carcinoma, not to size of the tumor. Over expression of E cadherin and loss of CD44v6 expression of the tumor suggests that the patient would have metastases.