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间质微血管密度与乳腺癌临床病理因素的关系 被引量:2

The relationship between microvessel density in mesenchyme and clinicopathological factors in breast carcinoma
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摘要 目的 :探讨乳腺癌微血管密度 ( MVD)与临床病理因素的关系。方法 :应用免疫组织化学S- P法 ,对 49例乳腺癌和 1 0例癌旁正常组织 MVD进行检测 ,并将其结果与影响预后的临床病理因素进行比较。结果 :乳腺癌 MVD明显高于癌旁正常组织 ( P<0 .0 1 ) ;乳腺癌 MVD与组织学分级、淋巴结转移呈正相关 ( P<0 .0 5 ) ,与患者年龄、肿瘤大小、组织学分型、临床分期、雌孕激素受体水平无关。结论 :乳腺癌 MVD可作为判定肿瘤生物学行为、转移潜能。 Objective: To study the relationship between microvessel density (MVD) and clinicopathological factors in breast carcinoma. Methods: Microvessel density was detected in 49 cases of breast carcinoma and 10 cases of normal tissue adjacent to tumor with immunohistochemical technique. Then compared the results with clinicopathological factors which affected the prognosis. Results: The MVD of breast carcinoma was significantly higher than that of adjacent non tumor normal breast tissue ( P <0.01) ; The MVD of breast carcinoma was associated with histological grade and lymph node metastasis , but no related to age, tumor size, histological type, clinical stage, estrogen and progesterone receptors. Conclusion: MVD of breast carcinoma is a referred indicator to determine tumor biological behavior, metastasis potential ,prognosis and clinical therapy.
出处 《吉林大学学报(医学版)》 CAS CSCD 北大核心 2002年第2期132-133,共2页 Journal of Jilin University:Medicine Edition
关键词 乳腺癌 间质微血管密度 免疫组织化学 病理 预后 breast carcinoma microvessel density in mesenchyme immunohistochemistry
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参考文献6

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同被引文献8

  • 1黄志清,阚秀,虞有智,董建强,麻为民.乳腺癌中PCNA表达及其与组织学分级的关系[J].临床与实验病理学杂志,1996,12(4):295-297. 被引量:25
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  • 8何旭,李玉林,张丽红.基质金属蛋白酶及其抑制剂在乳腺癌中的表达及意义[J].吉林大学学报(医学版),2003,29(6):753-755. 被引量:16

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