摘要
目的 :探讨乳腺癌微血管密度 ( MVD)与临床病理因素的关系。方法 :应用免疫组织化学S- P法 ,对 49例乳腺癌和 1 0例癌旁正常组织 MVD进行检测 ,并将其结果与影响预后的临床病理因素进行比较。结果 :乳腺癌 MVD明显高于癌旁正常组织 ( P<0 .0 1 ) ;乳腺癌 MVD与组织学分级、淋巴结转移呈正相关 ( P<0 .0 5 ) ,与患者年龄、肿瘤大小、组织学分型、临床分期、雌孕激素受体水平无关。结论 :乳腺癌 MVD可作为判定肿瘤生物学行为、转移潜能。
Objective: To study the relationship between microvessel density (MVD) and clinicopathological factors in breast carcinoma. Methods: Microvessel density was detected in 49 cases of breast carcinoma and 10 cases of normal tissue adjacent to tumor with immunohistochemical technique. Then compared the results with clinicopathological factors which affected the prognosis. Results: The MVD of breast carcinoma was significantly higher than that of adjacent non tumor normal breast tissue ( P <0.01) ; The MVD of breast carcinoma was associated with histological grade and lymph node metastasis , but no related to age, tumor size, histological type, clinical stage, estrogen and progesterone receptors. Conclusion: MVD of breast carcinoma is a referred indicator to determine tumor biological behavior, metastasis potential ,prognosis and clinical therapy.
出处
《吉林大学学报(医学版)》
CAS
CSCD
北大核心
2002年第2期132-133,共2页
Journal of Jilin University:Medicine Edition
关键词
乳腺癌
间质微血管密度
免疫组织化学
病理
预后
breast carcinoma
microvessel density in mesenchyme
immunohistochemistry