PCNA、MSH2和Fas-L基因在肺癌组织中的表达及意义

The significance of expression of PCNA,MSH2 and Fas-L gene in lung cancer tissues

目的 :探讨判定肺癌患者预后的分子生物学指标。方法 :通过免疫组织化学方法观察PCNA、MSH2和 Fas- L在肺鳞癌、腺癌、小细胞癌中的表达。结果 :在肺鳞癌、腺癌和小细胞癌中PCNA、Fas- L表达高于正常组 ( P <0 .0 1 ) ,小细胞癌 PCNA和 Fas- L表达高于鳞癌、腺癌( P<0 .0 5 ) ;而鳞癌与腺癌比较差异无显著性 ( P>0 .0 5 )。 MSH2在三种癌之间及三种癌与正常组之间差异无显著性 ( P>0 .0 5 )。结论 :PCNA和 Fas-

Objective: To explore the moleculobiological criterion evaluating the prognosis of patients with lung cancer.Methods: The expression of PCNA,Fas L and MSH2 were detected in sqamous cell carcinoma, adenocarcinoma and small cell carcinoma. Results:The expression of PCNA and Fas L in above three cancer cells was higher than that in control group ( P <0 01), difference in the expression of PCNA and Fas L between small cell carcinoma and sqamous cell carcinoma or adenocarcinoma was significant ( P <0.05) ,but the difference in expression of both PCNA and Fas L was not significant between sqamous cell carcinoma and adenocarcinoma ( P >0.05). The expression of MSH2 had no difference among above three cancers or between cancers and normal group. Conclusion: Both PCNA and Fas L can be used as a moleculobiological predictor in assessment of lung cancer prognosis.