低剂量电离辐射对松果腺调节睾丸酮的影响

Effect of low dose radiation on pineal gland in regulation of serum testosterone level

目的 :探讨低剂量 X射线全身照射对小鼠松果腺调节睾丸酮 ( TS)的影响。方法 :采用放免分析法检测低剂量电离辐射免疫兴奋效应的动物模型血清 TS。结果 :血清 TS在照射后 4h开始升高 ,8h达峰值 ( P<0 .0 1 ) ,1 2 h降至正常 ,2 4 h再次升高 ( P<0 .0 5 ) ,呈双峰变化趋势。结论 :低剂量电离辐射可引起松果腺调节功能增强 ,进而引起下丘脑 -垂体 -性腺轴功能变化 ,TS水平升高。

Objective: The effect of low dose radiation (LDR) on pineal gland in regulative function of testosterone (TS) in mice was determined in the study. Methods: The distribution of TS in the serum was analyzed by radioimmunoassay after WBI with 75 mGy X rays. Results:Since 4 h after WBI the TS levels of serum in mice increased up to its highest peak at 8 h ( P <0.001), then returned to the sham irradiation levels 12 h late,however, increased again after 24 h ( P <0 05), resulted in two peaks.Conclusion: The results indicated that whole body low dose radiation might stimulate the regulative function of pineal gland and sex gland, increasing the level of TS.