脑血栓患者t—PA与PAI的测定及其临床意义

The Determinations of the Activities of tissue-type Plasminogen Activator and Plasminogen Activator Inhibitor and Their Clinical Significances in Patients with Cerebral Thrombosis.

为探讨脑血栓患者纤溶系统功能的异常变化,我们采用发色底物显色法测定了24例脑血栓急性期与恢复期的患者t—PA与PAI的活性,并与15例正常人进行对照。结果:脑血栓组t—PA活性与对照组无明显差异,而血浆PAI活性,在脑血栓急性期明显高于对照组(P<0.001),恢复期血浆PAI活性虽下降,但仍高于对照组(P<0.05)

In order to inquire into the abnormal changes in the fibrinolytie system of cerebral thrombotic patients, we had determined the activities of tissue-type plasminogen activator (t-PA) and plasma plasminogen activator inhibitor (PAI) by means of spectrophctometrcr assay in24 cases of cerebral thrombotic patients during active and restoration stages, and 15 bases of normal individuals were used as controls. The results revealed that there was no obvious difference in the activities of t-PA in the thrombotic group and the control group. But the plasma PAI activity in the acute cerebral thrombotic group was obviously higher than that of normalcontrol group. (P<0.001). In the restoration stage, though the plasma PAI activity decreased already, but it was still higher than that of control group (P<0.05).