摘要
研究了恩诺沙星长效注射液给猪肌注后的药物动力学特征。将12只白猪随机分成两组,每组6只,分别肌注恩诺沙星注射液(5mg/kg)和长效恩诺沙星注射液(18.75mg/kg),并于给药后0.1, 0.25, 0.5, 1, 2, 4, 8, 12, 24, 36, 48, 60h, 从前腔静脉采取5ml血,用HPLC分析各血浆样品中的药物浓度,用MCPKP软件计算药动学参数。结果表明:长效恩诺沙星注射液肌注后,经5.64h达到4.86μg/ml的最高浓度,吸收半衰期和消除半衰期分别为2.42h和19.47h,有效浓度维持时间为128.73h, AUC为166.96mg/L.h。吸收半衰期显著延长(p<0.05),达峰时间极显著推迟(p<0.01),消除半衰期也显著长于恩诺沙星注射液。
The pharmacokinetic properties of enrofloxacin long acting injection were studied. Twelve pigs were dividedinto two groups with 6 pigs in each. The pigs in one group were administered muscularly with enrolfloxacin injection indose of 5mg/kg, those in another group were administered with enrofloxacin long acting injection in dose of 18.75mg/kg.0.1, 0.25, 1, 2, 4, 8, 12, 24, 36, 48, 60 h after administration, blood samples were collected from front cavity veins, 5ml eachtime. The drug concentrations in plasma were analyzed by HPLC, and then the pharmacokinetic parameters were calcu-lated by using MCPKP software. After adminitration of enrofloxacin long acting injection, the time to reach maximumplasma concentration, the maximum plasma concentration, the absorption half life, elimination half life, the persisting timeabout effective concentration, and AUC were 5.64h, 4.86μg/ml, 2.42h, 19.47h, 128.73h, 166.96mg/L.h, respectively. Theresults suggested that, the absorption and elimination half-life of enrofloxacin long acting injection was longer than that ofenrofloxacin injection, significantly (p<0.05), and the time to reach maximum plasma concentration was significantlydifferent too (p<0.01).
出处
《中国兽药杂志》
2002年第4期21-23,共3页
Chinese Journal of Veterinary Drug
