创面愈合的评价指标

Evaluation criterion of wound healing

为建立客观、准确地评价创面愈合的标准,该文对近年来国内外有关文献进行检索,总结和筛选了创面愈合率、创面愈合时间、组织病理学分析、巨噬细胞定量分析、羟脯氨酶含量测定、细胞增殖情况、细胞DNA含量和细胞周期分析、转化生长因子-α水平、白细胞介素-1、白细胞介素-6和肿瘤坏死因子水平、角质细胞胶原酶-1含量测定、成纤维细胞生长因子受体-1水平、单核细胞化学诱导蛋白-1水平和角质细胞纤溶酶原活化抑制剂-2水平等13种创面愈合评价指标。其中创面愈合率、创面愈合时间及组织病理学分析仍是最直接而有效的创面愈合评价指标。

To set up some objective and accurate criteria to evaluate wound healing.Documents about wound healing were reviewed and summarized in detail.Wound healing rate, wound healing time, histopathology analysis, quantity assay of macrophage, determination of hydroxyproline. proliferation of cell, assay DNA contents and circle of cells, level of transforming growth factor α,levels of interleukin 1,interleukin 6 and tumor necrosis factor, assay of keratinocyte collagenase 1,level of fibroblast growth factor receptor 1,level of monocyte chemo attractant protein 1 and level of keratinocyte plasm inogen activator inhabitor type 2 were selected as the evaluation criteria of wound healing.Wound healing rate, wound healing time and histopathology analysis are direct and efficient criteria of wound healing.