玻璃酸钠黏弹性补充治疗膝骨关节炎改善关节功能的探讨

Viscosupplementation with sodium hyaluronate for the treatment of osteoarthritis of the knee

目的评价4种玻璃酸钠(sodiumhyaluronate,SH)注射液治疗膝骨关节炎(osteoarthritis,OA)的临床疗效。方法80例膝OA患者随机分成Ⅰ、Ⅱ、Ⅲ、Ⅳ组,分别接受欣维可(Synvisc)、施沛特(Sofast)、阿尔治(Artz)和益术康(Yishukang)关节腔注射。并于治疗前、治疗第3、5周和治疗结束后1月时随访,评估关节疼痛和功能情况。结果所有患者在关节疼痛和功能方面均取得了较满意的治疗效果,各组间无明显差异。比较而言,施沛特更为经济。结论SH关节腔内注射治疗OA是一种安全有效的治疗方法。

Objective To evaluate the clinical effect of viscosupplementation with 4 different brands of SH injections in treating osteoarthritis (OA) of the knee intra articularly. Method 80 patients with OA of the knee were divided randomly into 4 groups, patients of groupⅠ were treated with Synvisc, patients of groupⅡ were treated with Sofast, patients of group Ⅲ were treated with Artz and patients of group Ⅳ were treated with Yishukang. Assessments of joint pain and function were evaluated respectively before treatment and the follow-up on the 3rd, 5th week after the first injection and the 1st month after the whole treatment finished. Result All groups showed significant improvements in the joint pain and function from baseline and did not differ from each other significantly. Compared to others in the expenditure on the treatment. Sofast is more economical. Conclusion Intra articular injection of SH was an effective method for the treatment of OA of the knee.