纳洛酮治疗新生儿休克临床观察及体会

Clinical Observation and Taste of Naloxone in Treatment of Neonatal Shock

目的:用纳络酮治疗新生儿休克,了解临床疗效。方法;将64例新生儿休克病人,分为纳洛酮治疗组32例,常规治疗组32例。纳洛酮治疗组在常规治疗的基础上静脉注射纳洛酮0.05～0。1mg/kg·次,重度休克病人30分钟后重复应用,中度休克病人1～2小时重复应用:病情好转后延长用药时间或用输液泵0.05～0.1mg/kg·h静脉维持,持续4～6小时,疗程2～3天。结果:纳洛酮治疗新生儿休克能提高治愈率,减少死亡率,明显优于常规治疗组(P<0.01)。结论:纳洛酮抢救新生儿休克能明显提高抢救成功率,安全范围大,未发现任何副作用。

Objective:In order to understand the clinical therapeutic effect of naloxone,we used nalo xone to treat neonatal shock. Methods;64 cases of neonafal shock were divided into the Naloxone thera-peutic group (32 cases) and routine therapeutic group (32 cases). Naloxone group was treated with rou-tine treatment by adding with naloxone 0. 05 ~ 0. 1 mg/kg by intrarvenous route. Savere shock patients were repeat applied with naloxone after 30 minutes. Moderately shock patients were repeatly applied with naloxone 1 ~2 hrs. After the patient's condition got improvement, the administration time of naloxone might be prolonged or maintaining intravenous administration of naloxone with infusion pump 0. 05 ~ 0. 1 mg/kg/hr,continuonsly for 4 ~6 hours,the course of treatment might last for 2 ~ 3 days. Results:Nalox-one could raise the cure rate and decrease the death rate in curing neonatal shock and the effects are clearly superion to routine group (P < 0. 01 ). Conclusion: Naloxone clearly raises the successful rate on saving neonatal shock, the process of treatment did not find any side effect.