血清组织多肽特异抗原水平与肺癌生物学行为的关系

Relation between the serum tissue polypeptide specific antigen level and the biological demeanour of lung cancer

目的 探讨血清组织多肽特异抗原 (TPS)水平与肺癌生物学行为的关系及其对肺癌的诊断价值。方法 采用酶联免疫吸附分析法 (ELISA)测定 69例肺癌患者及 2 0例作为对照的肺结核及肺炎患者血清TPS水平。结果 肺癌患者血清TPS水平 (2 73± 1 72 )U/L明显高于对照组患者[(1 1 5± 97)U/L ,P <0 0 0 1 ] ;52例发生转移的肺癌患者其血清TPS水平 (30 1± 1 2 7)U/L显著高于未转移者 [(1 83± 97)U/L ,P <0 0 1 ] ;TNM分期的Ⅲ期、Ⅳ期患者组TPS水平显著高于Ⅰ～Ⅱ期患者组(P <0 0 1 ,P <0 0 0 1 ) ;TPS与肺癌的组织分型有关 ,小细胞肺癌组患者TPS水平 (346± 1 63)U/L显著高于非小细胞肺癌组患者 [(2 4 8± 1 65)U/L ,P <0 0 5] ;1 6例接受化疗的肺癌患者化疗后TPS水平(1 78± 80 )U/L显著低于化疗前 [(2 52± 1 66)U/L ,P <0 0 5] ;TPS与癌胚抗原 (CEA) (P <0 0 1 )、神经元特异烯醇化酶 (NSE) (P <0 0 5)和组织多肽抗原 (TPA) (P <0 0 5)呈正相关 ,但与 1 9片段角质蛋白(CYFRA 2 1 1 ) (P >0 0 5)无明显相关。结论 血清TPS含量与肺癌临床分期、组织分型及转移密切相关 。

Objective To investigate the relation between the serum tissue polypeptide specific antigen and the biological demeanour of lung cancer and analyze its clinical meaning for diagnosis of lung cancer Methods By ELISA, the serum TPS was tested in 69 patients with lung cancer, 20 patients with pulmonary tuberculosis or pneumania Results The serum TPS in patients with lung cancer (273±172) U/L was significantly higher than the with benign lesions [(115±97) U/L, P <0 001] TPS level was related to clinical TNM stages and histological grades It was significantly higher with TNM Ⅲ,Ⅳ stages than that with Ⅰ and Ⅱ stages ( P <0 001) The contents of TPS in sera of 52 patients with lymphoid node metastasis were apparently higher than those of 17 cases without metastasis ( P <0 01) And it was higher in patients with small cell lung cancer (346±163) U/L than that with non small cell lung cancer [(248±165) U/L, P <0 05] 16 post chemotherapy patients show a lower TPS[(178±80) U/L] than pre chemotherapy [(252±166) U/L, P <0 05]. TPS was related with CEA ( P <0 01), NSE ( P <0 05) and TPA( P <0 05), but not with CYFRA 21 1 ( P >0 05). Conclusion Serum TPS level is closely connected with TNM stages, histological grades and lymphoid node metastases and may serve as a novel marker for diagnosis of lung cancer