广东城乡病人中分离的幽门螺杆菌对常用3种抗菌药物耐药的调查

Investigation of the resistance of Helicobacter Pylori to three antibiotics in Guangdong province.

目的:比较广东城乡幽门螺杆菌(Hp)对常用3种抗菌药物的耐药情况。方法:分别用琼脂稀释法和E-test法检测广东城乡164株Hp对甲硝唑、克拉霉素及阿莫西林的耐药情况。结果:广东地区Hp对甲硝唑和克拉霉素的耐药率分别为51.8%和6.1%,城乡两地Hp对甲硝唑和克拉霉素的耐药率均无统计学差异(P>0.05),性别、年龄及病种对甲硝唑的耐药率无影响(P>0.05);在所有的Hp菌株中,仅发现1株对阿莫西林耐药。结论:广东无论城乡Hp对甲硝唑耐药均已相当普遍,对克拉霉素耐药也有增加的趋势,且已发现了对阿莫西林的耐药株,故应尽快建立完善的监测系统。

Objective:To compare the prevalence of antibiotic resistance of Helicobacter pylori (Hp) in urban and rural areas in Guangdong province. Methods:Sensitivity of 164 strains of Hp isolates to clarithromycin,amoxicillin and metronidazole was measured by E test and agar dilution method respectively. Results:Primary resistance rate of Hp to metronidazole and calrithromycin was 51.8% and 6.1% respectively. There was no statistically significant difference between resistance rates to metronidazole and to clarithromycin in both urban and rural areas (P>0.05). Gender,age and diagnosis had no influence on resistance rate to metronidazole (P>0.05). Only one Hp isolate was resistant to amoxicillin. Conclusions:In both urban and rural areas in Guangdong Province,metronidazole resistance of Hp is very common and there is an increasing tendency of clarithromycin resistance. Hp isolate resistant to amoxicillin has emerged. Therefore,there is pressing to set up an effective surveillance system for antibiotic resistance.