乳腺癌中癌胚抗原(CEA)与p53、nm23-H1蛋白表达和部分病理指标的相关性研究

RELATIONSHIP OF p53, nm23-H1 PROTEIN AND CEA EXPRESSION WITH VARIOUS PROGNOSTIC FACTORS IN BREAST CANCER

利用免疫组织化学方法检测了乳腺癌 CEA与 p5 3和 nm2 3- H1蛋白的表达 ,对其相关性进行了研究 ,同时与其它病理指标亦进行了比较。结果 :82例乳腺癌中 ,CEA阳性者 6 7例 (82 % ) ,与 p5 3蛋白的表达呈显著的负相关 (P<0 .0 5 ,而与 nm2 3- H1蛋白的表达则呈显著的正相关 (P<0 .0 5 ) ;同时 ,CEA的表达与肿瘤的病理分级和体积显著相关 (P <0 .0 5 ) ,即分级越高或肿瘤越大 ,CEA阳性表达率越低 ;而与患者年龄、淋巴结转移和肿瘤坏死程度无关 (P>0 .0 5 )。综合分析推测 :CEA可能是乳腺癌一种高分化肿瘤标志 ,并与肿瘤的浸润转移潜能有一定的关系 ,与其它指标联合应用在判断乳腺癌预后中有一定的价值。

The relationship of p53, nm23-H1 protein and CEA expression was studied in 82 cases of breast cancer by immunohistochemical method. Furthermore, the correlation with various prognostic factors was investigated. The result showed that CEA positivity was significantly correlated with p53 protein negativity and nm23 H1 protein positivity ( P <0 05). The expression of CEA was significantly associated with low histologic grade and small size of tumor ( P <0 05). The expression of CEA was not correlated with PCNA index, the age, axillary lymph node metastases and necrosis ( P >0 05). These data suggest that CEA appears to be a marker of high differentiation in breast cancer, and may be correlated with the invasive and metastatic potency. So it may be used to predict the prognosis of breast cancer in combination with other methodology