摘要
雷米普利及其双酸制剂在10^(-5)mol/L时,对离体豚鼠工作心脏各心功能参数均无明显影响。将以上两种制剂分别静脉注射和腹腔注射2mg/kg,20min后可改变垂体后叶素所致的大鼠急性心肌缺血时的心电图,减少大鼠结扎冠状动脉所致心肌梗塞区域。结果表明:雷米普利及其双酸制剂对离体豚鼠心肌收缩性能无明显作用,而对急性心肌缺血似有一定保护作用。
Various cardiac function parameters in isolated working quinea pig heart were not affected by Ramipril and Diacid-ramipril 10-5 mol/L. Ramipril and Diacid-ramipril 2 mg/kg iv and ip, respectively, changed ECG of pituitrin (1 U/kg, iv) induced acute myocardial ischemia in rats, decreasing the size of infarction by coronary ligation in rats The above findings suggest that Ramipril and Diacid-ramipril effectively protect animal from experimental infarction.
出处
《同济医科大学学报》
CAS
CSCD
北大核心
1991年第1期21-24,共4页
Acta Universitatis Medicinae Tongji
关键词
雷米普利
心肌缺血
药理学
ramipril
coronary disease, isolated working quinea pig heart
pharmacology
