钙调蛋白抑制剂(氯丙嗪)增敏热化疗的动物实验研究

The Enhanced Effect of Calmodulin Inhibitor (Chlorpromazine) on Thermochemotherapy in Mouse Tumor

本文介绍了钙调蛋白抑制剂(氯丙嗪)增敏热化疗治疗恶性肿瘤的动物实验。结果表明:单纯加热治疗对S180的生长有一定的抑制作用;氯丙嗪联合热化疗疗效明显优予热化疗,实验还探讨了氯丙嗪在热化疗前或后及前后均使用及使用长短的意义,结果显示疗效按前后处理、后处理、前处理逐步降低,作用时间长疗效增加。作者复习了有关文献认为,前处理仅为相加作用,后处理有增敏作用,前后同时处理则综合了这两方面的作用。氯丙嗪对热化疗的增敏作用是明显的,可望用于恶性肿瘤的综合治疗。

An experimental study of the CaM inhibitor (chlorpromazine) enhansing thermochemotherapy is reported in this paper. It was found that hy-perthermia alone has some inhibitory effect on the growth of the mouse tumor S180. Thermochemotherapy combined with chlorpromazine has better effect than thermochemotherapy. The significance of the use of chlorpromazine before or after thermochemotherapy or before and after it, and the duration of treatment with chlorpromazine were also studied. The therapeutic effect gradually decreased in pre- and post-treatment, post-treatment and pre-treatment. The longer the treatment with chlorpromazine, the better the effect. From the foregoing it may be suggested that the pre-treatment exerts only an additional effect; the post-treatment an enhanced effect; and the pre- and post-treatment at once produces an enhanced as well as an additional effect. The enhanced effect of chlorpromazine on thermochemotherapy is very significant. As a result, this method can be used to treat malignant tumors clinically.