湖北贝母属植物化学成分的研究——鄂贝新的结构解析

Studies on Chemical Constituents of Fritillaria in Hubei Province: A Structural Analysis of Ebeiensine

作者从鄂北贝母及其变种紫花鄂北贝母中分离到相同结构的生物碱,C_(27)H_(41)NO_3,mp228～230℃。在IR、MS、~1H-NMR和^(13)C-NMR解析的基础上,确定分子结构为5α,14α,20β-jervanine(N-αH)-3β-hydroxy-6-one(1),命名为鄂贝新(ebeiensine)。该结构经X-衍射单晶分析进一步证实。

To continue our studies on the chemical constituents of Fritillaria in Hubei Province, a new jervanine skeleton alkaloid, C27H41NO3, mp 228-230℃, named ebeiensine, was isolated from the bulb of Fritill aria ebeiensis G.D. Yu et G. Q. Ji and Fritillaria ebeiensis var. purperea G.D. Yu et P. Li.The structure of ebeiensine has been established as 5α, 14α, 20β-jervanine (N-αH)-30-hydroxy-6-one(1) on the basis of its IR, 1H-NMR, 13C-NMR and mass spectra. The X-ray crystallography analysis of 1 has also been accomplished. The crystal of 1 belongs to the orthorhombic system with space group P212121, and cell dimensions, a = 6.6198, b=15.1798, C=25.3253A. β=90°, V = 2636.4 (A3), Z = 4, R=0.055.