四种宫内节育器引致兔子宫活动及前列腺素含量的动态变化

Dynamic Changes of Myometrial Activity, Levels of PGF_(2α) and PGE_2 in Rabbits after Insertion of 4 Types of IUDs

观察放置4种宫内节育器后,各组兔子宫机械与电活动的变化,并对各组兔宫腔冲洗液进行PGF_(2α)及PGE_2放射免疫测定。结果:带器早期子宫活动增强,随后逐渐趋于平稳,其强度为Cu-IUD>SS-IUD>LNG-Cu-IUD>LNG-IUD。PGF_(2α)及PGE_2水平:在早期,Cu-IUD>SS—IUD>LNG-Cu-IUD>LNG-IUD;带器后4月,各组水平均下降。提示:置器早期子宫收缩性增强可能与脱落等副作用相关,IUD所释铜离子能增强子宫活动及提高PGF_(2α)和PGE_2水平,LNG则减少之。此结果显示了发展LNG-Cu-IUD的可行性。

Myometrial activity, levels of PGF2α and PGE2 in uterine flushings were measured in rabbits before and after insertion of four types of IUDs. The results showed that IUDs could increase the uterine contraction during early stage of insertion. Thereafter, the uterine activity tended to be stable. The sequence of uterine contractility generally were. Cu-IUD>SS-IUD>LNG^Cu-IUD>LNG-IUD. The measurement of prostaglanding, determined by RIA, indicated that the concen-trations of PGF2α and PGE2 in Cu-IUD and SS-IUD groups were higher than those in the controls in the early phase of insertion, which was no more found four months after use. Our results suggested that hyperactivity of the uterus in early stage after insertion of IUDs might be relevant to side-effects like expulsion and pain. Copper released by Cu-IUD stimulates the uterine activity partially through increasing PGF2α and PGE2 contents. In rabbits wearing LNG-IUD or LNG-Cu-IUD, both PGF2α and PGE2 levels were low. The relatively low uterine mechanical and electrical activities were also observed in these two groups. Based on these data, it may be concluded that the development of LNG-Cu-IUD for reducing expulsion of IUDs is feasible.