女性男性化疾病的内分泌测定

The Hormone Measurement for Androgenic Women

本文对51例男性化妇女测定了睾丸酮、游离睾丸酮、雄烯二酮、17α-羟孕酮、硫酸脱氢表雄酮(DHAS)、性激素结合蛋白(SHBG)、雄甾烷二醇和游离雄激素指数(FAI)。男性化妇女伴有高雄激素者92％有明显的SHBG值降低,且FAI明显升高,雄烯二酮和17α-羟孕酮无明显变化,17例雄甾烷二醇值均高于正常,且与睾丸酮和游离睾丸酮有密切相关性(γ=0.78,γ=0.80)。对于女性男性化病例的诊断除测定睾丸酮和DHAS外,还应测定SHBG和FAI。

Presented in this paper is an assay of total testosterone, andros-tanedione, free testosterone 17α-hydroxyprogesterone, dehydroepiandrosterone-sulfate (DHAS), sex-hormone-binding-globulin (SHBG), androstanediol and free androgen index (FAI) in 51 women with hirsutism. 92 % of the hirsute women with elevated androgen level showed obvious decrease in SHBG values, increase in FAI but no changes in androstanedione and 17α-hydroxyprogesterone values. 17 females with hirsutism revealed abnormally high androstanediol values which are closely related to those of total and free testosterone (r=0.78, r=0.80). Besides testosterone and DHAS, SHBG and FAI should also be measured in the diagnosis of androgenic cases.