α和β受体阻断剂对大鼠室颤阈值的影响

Effects of a and β Adrenoreceptor Blocking Agent on the Value of Ventricular Fibrillation Threshold in Rats

用α和β受体阻断剂,观察对麻醉大鼠心室纤颤(下称室颤)阈的影响。大鼠分两组,A组先用β受体阻断剂,30min后加用α受体阻断剂。B组用药顺序与A组相反,A组用药前室颤阈值4.69±2.20mA,静注β受体阻断剂后10min室颤阈提高为6.13±2.47mA(P<0.05)。静注后30min室颤阈降为4.00±1.69mA,此时加用α受体阻断剂,10min后室颤阈又提高为5.88±2.36mA(P<0.05)。B组用药前后室颤阈值测定差异无显著性(P>0.05)。结果提示:β受体阻断剂可提高大鼠的室颤阈,α受体阻断剂在β受体阻断剂作用基础上能提高反复致颤心脏的阈值。

By using the α and β adrenoreceptor blocking agents, the effects on the value of ventricular fibrillation threshold (VFT) were observed in anesthetized rats. The animals were divided into group A and B. In group A, P adrenoreceptor blocking agent was used. 30 min after administration, a adrenoreceptor blocking agent was added. In contrast, α adrenoreceptor blocking agent was administered first to group B, followed by β adrenoreceptor blocking agent. Before using medicine, the VFT was 4.99±2.20 mA. 10 min after administration of 0 adrenoreceptor blocking agent, the VFT increased to 6.13±2.47 mA (P<0.05), and 30 min later, it decreased to 4.00±1.69 mA. At this time,the a adrenoreceptor blocking agent was added. 10 min later, it increased to 5.88±2.36 mA (P<0.05). In group B, before or after using medicine, the value of VFT demonstrated no significant difference (P<0.05). The above findings suggest that the β adrenoreceptor blocking agent increased the value of VFT in rats, and so did the a adrenoreceptor blocking agent the value of repeated VF on the basis of the action of the β adrenoreceptor blocking agent.