不同形态的^(111)In在小鼠体内动态分布的观察

OBSERVATION OF THE DYNAMIC DISTRIBUTION OF DIFFERENT FORMS OF ^(111)In IN MICE

单克隆抗体,^(111)In标记物,游离^(111)In,代谢。

The dynamie distribution in mice of three forms of ^(111)In——^(111)In-labelled monoclonall antibody, ^(111)In-DTPA and ^(111)In-citrate (free ^(111)In)——has been studied, ^(111)In-DTPA was eliminated rapidly and the ra- dioactivity was reduced to the background level in all organs in 6 hours (only small amount in the liver and kidneys). The metabolism of free ^(111)In was different from that of ^(111)In-labelled antibody, showing higher elimination rate in the blood than the later although both accumulated in the liver and kidneys. The result suggests that the radioactivity of ^(111)In in the liver is a combined mechanism of metabolism of labelled antibody in the liver and the transportation of free ^(111)In in the blood to the liver. It also shows the possibility of accelerating the elimination of nonspecific radioactivity in the liver with metal chelators.