^(169)Yb,^(141)Ce示踪的稀土元素在小鼠体内的分布及与鼠肝蛋白的结合

DISTRIBUTION AND COMBINATION OF RARE EARTHS WITH LIVER PROTEIN IN MICE TRACED BY ^(169)Yb AND ^(141)Ce

本工作通过给小鼠饲喂以^(169)Yb,^(141)Ce核素示踪的含稀土食物,以及分别注射入含这些放射性核素的溶液,从而测定稀土元素在小鼠体内的分布与积累情形。在饲喂试验中,观察到97%以上的稀土被排出体外,被吸收的少量镱主要积蓄在骨和肌肉中,铈偏于肌肉。由静脉注射入小鼠体内的镱多积蓄于肝、脾和骨;铈主要分布于肝和脾,而骨中则明显减少。随着提取出一种与镱或铈相结合的鼠肝蛋白,测得该稀土蛋白的分子量为61000。

The distribution and accumulation of rare earth elements in mice were determined by means of counting the radioactivity of ^(169)Yb and ^(141)Ce, which were added as tracer of R. E. in the diet or injected into the veins of mieeo In the feeding experiments, more than 97% amount of R. E. was excreted, only a small amount of ytterbium was accumulated in bone and muscle, while cerium principally in muscle. The results of injection into veins showed that most of ytterbium was distributed in liver, spleen and bone, and cerium concentrated in the same tissues except bone. On the basis of above experiments, a protein binding ytterbium or cerium was extracted from liver of mice, and a molecular weight of 61000 was determined.