糖化血清蛋白和肿瘤坏死因子与2型糖尿病并发脑梗死的关系

Association between serum glucosylated serum proteins and tumor necrosis factor and 2type diabetes mellitus with acute cerebral infarction

目的 探讨糖化血清蛋白 (GSP)和肿瘤坏死因子 (TNF -α)水平与 2型糖尿病伴发脑梗死 (ACI)的关系。方法 用酮氨氧化酶法 (KAO)和放射免疫法 (RIA)分别测定 30例正常人和 32例 2型糖尿病无并发症患者 ,36例伴发脑梗死患者的血清GSP和TNF -α水平。结果 对照组血清GSP水平为 (2 5 2 2 0± 38 39) μmol/L ,TNF -α水平为 (1 12± 0 2 1) μg/L ;2型糖尿病无并发症患者GSP水平为 (333 6 7± 2 2 2 9) μmol/L ,TNF -α为 (1 77± 0 16 ) μg/L ,2型糖尿病伴发脑梗死患者GSP水平为 (4 17 6 6± 18 71) μmol/L ,TNF -α为 (2 5 9± 0 14) μg/L。统计学结果表明对照组、2型糖尿病无并发症组与伴有脑梗死组间血清GSP和TNF -α有显著差异 (P <0 0 1)。结论 高GSP和TNF -α水平与 2型糖尿病伴发脑梗死具有一定的相关性。

Objective To explore the relationship between serum glucosylated serum proteins (GSP),tumor necrosis factor (TNF-α) and 2 type DM with acute cerebral infarction(ACI). Methods Using KAO and RIA, serum GSP and TNF-α levels were determined in 30 normal subjects, 32 2DM without angiopathy and 36 with ACI. Results The mean serum GSP level was (252.20±38.39) μmol/L, TNF-α level was (1.12±0.21) μg/L in normal subjects; GSP (333.67±22.29) μmol/L and TNF-α(1.77±0.16) μg/L in 2 type DM patients without angiopathy; GSP (417.66±18.71) μmol/L and TNF-α(2.59±0.14) μg/L in 2DM patients with ACI. The GSP and TNF-α levels of three groups showed that there was a significant difference between the 3 groups (P<0.01).Conclusion The elevated levels of serum GSP and TNF-α may be related to the diabetic patients with ACI.