158例慢性肾衰竭的中西医结合治疗

Treatment Report of 158 Cases Chronic Renal Failure by Combination of TCM and Western Medicine Therapy

目的 :探讨西医疗法加用中药肾衰方治疗慢性肾衰竭 (CRF)的临床疗效。方法 :2 70例CRF病人随机分为治疗组和对照组。治疗组 (15 8例 )在西医治疗的基础上加用中药肾衰方 ,对照组 (10 2例 )单纯用西医治疗。结果 :治疗组血清尿素氮 (BUN)和血清肌酐 (Scr)较治疗前显著下降 (P <0 .0 1,P <0 .0 5 ) ,血肌酐倒数 (1/Scr)与时间(前 3个月 )回归分析 ,斜率b为正值 2 .6× 10 -4,表明能延缓CRF的进展 ,部分病人肾功能还有所改善。临床综合评价 ,总有效率为 83.5 4 % ,显著优于对照组 6 5 .6 9% (P <0 .0 1) ,3年以上的转归 ,终末期肾衰 (ESRD)发生率 18.5 2 % ,显著优于对照组的 37.84 % (P <0 .0 5 )。结论

Objective:To investigate the effect of combination of the western medicine treatment and the Traditional Chinese medicine Shengshuai recipe on chronic renal failure (CRF).Methods:270 cases of CRF were randomly divided in to two group,therapy group and control group.Therapy group (158 cases) was added with the Traditional Chinese Medicine Shengshuai recipe on the base of western medicine treatment,control group (102 cases) was treated with western medicine treatment only.Results:In therapy group patients,the blood uria nitrogen and creatinine were much higher as compared with the level before therapy.( P<0.01,P <0.05),The regression analysis between reciprocal of creatinine and time(in 3 months)showed the slope(b) is positive number(2.6×10 -4 ).This shows the drug could delay the course of CRF,The renal function of some patients got better.In all,the rate of efficienly is 83.54%.better than the control group 65.69% ( P<0.01 ).When analyze the result after 3 years,in therapy group the incidence of end-stage renal disease (ESRD) is 18.52%,better than that of the control group 37.84% ( P <0.05).Conclusion:The Traditional Chinese Medicine Shengshuai recipe lomibined with western medicine therapy treats patient better than the way used western medicine only in non-dialysis patient.