低蛋白饮食对慢性肾衰竭患者透析前临床状态的影响

Low-protein Diets Ameliorate Predialysis Clinical Status in Chronic Renal Failure Patients

目的 :探讨低蛋白饮食对慢性肾衰竭 (CRF)患者透析前临床状态的影响。方法 :CRF患者 4 4例。治疗 (T)组 :11例 ,实施以低蛋白饮食 (0 .6 g·kg-1·d-1)为主的综合治疗 11～ 2 0个月直至透析 ;对照 (C)组 :2 3例 ,未经饮食限制的CRF患者。采用尿尿素氮监测患者蛋白饮食的依从性 ,观察T组治疗前后营养状况变化 ,比较T、C二组患者的透析前临床状态。结果 :(1)T组患者实际蛋白摄入量为 (0 .6 4± 0 .10 ) g·kg-1·d-1;(2 )T组治疗前后营养状况无明显变化 ;(3)与C组相比 ,T组患者透析前营养状况良好 ,且恶心、水肿和出血倾向发生较少。结论 :以低蛋白饮食为主的综合治疗不引起营养状况恶化 。

Objective:To investigate impact of low-protein diets on predialysis clinical status in chronic renal failure patients.Methods:We designed a 11～20 months compositive therapy that using low-protein diets (0.6 g·kg -1 ·d -1 ) as central therapy until dialysis in 11 patients with chronic renal failure,23 predialysis chronic renal failure patients who had not received dietary interventions as controls.We measured the compliance with the suggested protein intake by urinary urea, investigated changes of the nutritional indices after therapy in T group patients,and compared the predialysis clinal status of patients between T group and C group.Results:(1)Actual mean protein intake was(0.64±0.10) g·kg -1 ·d -1 in T group patients;(2)There were no obvious changes on nutritional indices after the therapy in T group patients;(3)Compared to controls ,the nutritional status was better and nausea,edema,bleeding tendency were little at predialysis time in T group patients .Conclusion:The compositive therapy that using low-protein diets as central therapy did not worsen the nutritional status,and ameliorated predialysis clinical status in chronic renal failure patients.