肾康灵冲剂治疗小儿频复发性肾病30例临床观察

Treatment of Frequently Recurrent Nephritic Syndrome in Children with Shenkangling Granula:An Observation on 30 cases

目的 :通过观察肾康灵冲剂治疗小儿FRNS的临床疗效 ,旨在探讨小儿FRNS的复发原因及中药治疗的作用机理。方法 :观察 6 0例小儿FRNS ,随机分为治疗组和对照组各 30例 ,治疗组加用中药肾康灵冲剂 ,观察 2组病例的复发情况及血浆皮质醇水平和CD4/CD8比值的变化。结果 :治疗组在 3个月后血浆皮质醇水平和CD4/CD8比值逐渐回升 ,激素停药后则明显高于治疗前 (t =11.75和 9.0 5 ,P均 <0 .0 1)。而对照组治疗前后无显著差异 (t=0 .194和 2 .36 ,P >0 .0 5 )。治疗组在 0 .5年、1年和 2年随访中的复发次数和复发率均明显低于对照组。结论 :补脾益肾中药肾康灵冲剂治疗FRNS患儿可以提高机体的抗病能力 ,纠正已经紊乱的免疫功能状态 ,拮抗外源性激素对HPA轴的反馈抑制 ,保护肾上腺皮质功能 。

Objective:To search the recurrent factors and its mechanism of FRNS in children by treatment of Shenkangling Granula.Methods:The diseased children (n=60) were randomly assigned into treatmeats group and control group on average.The former group was treated with Shenkangling Granula in addition to the latter.Then the plasma/serum corticoid and CD 4/CD 8 were determined and the recurrence was followed in both cases.Results:The serum corticoid and CD 4/CD 8 increased gradually 3 months later and markedly higher than those before treatment in treatment group ( t=11.75 and 9.05,P< 0.01 both),while there was no statistical significance in control group ( t=0.194 and 2.36, P>0.05 both).And the recurrences of the disease during 0.5,1 and 2-year follow-up in treatment group were distinctly fewer than those of control group.Conclusion:Shenkangling Granula which benefits the spleen and kidney can reduce the infection and recurrence rates of FRNS in children by enhancing the ability to resist disease,redressing the disturbed immunological function status,counteracting the feedback inhibition of HPA Axis by ectogenesis hormone and protecting the function of adrenal gland.