摘要
目的 探讨脉络丛乳头状瘤 (choroid plexus papilloma,CPP)临床病理学特点、免疫组化表型与诊断。方法 对 1例尸检发现的侧脑室脉络丛乳头状瘤进行组织病理 (HE)及免疫组化 (Envision法 )观察。结果 死婴出生 18d,肿瘤发现于侧脑室 ,呈暗红小结节状 ,伴脑室积水。镜下肿瘤组织呈分支乳头状 ,酷似脉络丛 ,细胞一致 ,乳头轴心血管丰富。免疫组化标记 :瘤细胞广谱 CK和 Vim阳性 ,S- 10 0强阳性 ,GFAP灶性阳性 ,EMA、34βE12和 CEA均阴性。结论 CPP是起源于脑室脉络丛的良性肿瘤 ,在婴儿好发于侧脑室 ,可产生大量脑脊液而引起脑积水与颅内压增高 ,镜下典型的脉络丛样乳头状结构和 CK、S- 10 0与
Objective To investigate the clincopathologic and immunohistochemical features and diagnosis of choroid plexus papilloma(CPP).Methods One case of CPP discovered in the lateral ventrical by autopsy was observed by HE stain and immunohistochemical technique (EnVision system).Results The tumor occurred in an 1 8-day old newborn with hydrocephalus and located in the lateral ventrica l,appearing as a red lobulated mass.Microscopically the tumor resembled choroid plexus and presented papillary patterns with uniform cells that were well vascularized.Immunohistochemical staining showed positive staining for pan kera tin and Vimentin,strongly positive for S-100 protein,locally positive for GFAP and negative for EMA,34βE12 and CEA.Conclusion CPPs,often located in the lateral ventricle in childhood,were benign neoplasms deriving from cerebral ventricle choroids plexus and could secrete excessive cerebrospinal fluid causing hydrocephalus and increased intracraniai pressure.The typical papillary structure under microscope and CK,S-100,Vimentin positive staining were helpful in its diagnosis.
出处
《中国误诊学杂志》
CAS
2002年第5期651-652,共2页
Chinese Journal of Misdiagnostics