利用山梨酸合成香料叶醇

Synthesis of Folic Alcohol from Sorbic Acid

叶醇及酯是重要而名贵的香料 ,可由山梨酸为原料通过化学合成的方法得到。山梨酸在无水乙醚溶液中用 Li Al H4作还原剂在 2 6～ 30°C下反应 1 .5 h,然后在 Mo( CO) 6的存在下在高压反应釜中进行选择性氢化反应 ,在温度 1 2 0～ 1 40°C下反应 5～

Folic alcohol and its derivatives are important and rare fragrance materials. It can be synthesized from sorbic acid. Sorbic acid was reduced by LiAlH 4 in absolute ether at 26～30 °C for 1.5 h, and then selectively hydrogenated at 120～140 °C for 5~6 h in an autoclave using Mo(CO) 6 as catalyst to give the product.