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环糊精对手性药物伪麻黄碱分子识别的电喷雾飞行时间质谱研究 被引量:13

Chiral Molecular Recognition of Cyclodextrin to Pseudoephedrine by Electrospray Time-of-Flight Mass Spectrometry
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摘要 用电喷雾正交飞行时间质谱仪分别研究了以α 环糊精、β 环糊精和γ 环糊精作为手性拆分剂对手性药物伪麻黄碱的分子识别效应 ,同时还分别研究了Nozzle电压的变化对α 环糊精、β 环糊精和γ 环糊精的手性识别的影响 .在质谱图中能明显反映出三种手性拆分剂都具备很强的手性识别能力 ,随Nozzle电压的改变 。 Electrospray time-of-flight mass spectrometry was employed to investigate chiral molecular recognition of pseudoephedrine using α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin as chiral selectors. The effect of nozzle potential on chiral recognition of cyclodextrins was also studied. Strong chiral recognition ability of these three cyclodextrins was revealed by the mass spectra based on the protonated complexes of pseudoephedrine with cyclodextrins. It was demonstrated that these three chiral selectors possess their individual chiral recognition characteristics when nozzle potential changed.
出处 《化学学报》 SCIE CAS CSCD 北大核心 2002年第5期882-885,共4页 Acta Chimica Sinica
基金 国家自然科学基金 (No .2 0 175 0 34) 中国博士后科学基金资助项目
关键词 手性药物 伪麻黄碱 分子识别 电喷雾飞行时间质谱 手性识别 环糊精 拟肾上腺素类药物 chiral recognition, cyclodextrin, electrospray ionization, time-of-flight mass spectrometry
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