脑瘫患儿骨碱性磷酸酶水平测定研究

Study on the Level of BALP in Chilbren with Cerebral Palsy

目的:探讨骨碱性磷酸酶(BALP)在小儿脑性瘫痪(CP)诊断与鉴别诊断中的价值及临床意义。方法:测定106例CP患儿及同期佝偻病患儿血BALP值,对于BALP≥240U/LCP患儿及BALP≥250U/L佝偻病患儿,一次性给予VitD_3 30万U及钙剂治疗,6周后复查BALP,比较两者BALP下降值。结果:CP及佝偻病患儿BALP值分别集中在210～260U/L,270～300U/L(P<0.001),年龄≤1岁和残疾程度重的CP患儿BALP值增高明显(P<0.05,P<0.001),治疗后CP及佝偻病患儿BALP平均下降值分别为39.80U/L及18.72U/L(t=4.06,P<0.001)。结论:CP患儿存在骨钙化障碍,年龄越小,残疾程度越重者,BALP升高越明显。

Objective:To study the diagnostic value and clinical significance of BALP level in children with cerebral palsy (CP). Method; Blood BALP concentrations were determined both in 103 CP children and in 35 rickets patients. Both CP children whose BALP concentration was 240U/L or higher and rickets patients whose BALP concentration was 250U/L or higher received Vitamin D3 30 000 U one time, and the same time got calcium treatment. BALP levels in two types of patients were checked six weeks after D3 treatment. Results: Main range of BALP concentration in CP children was 210U/L - 260U/L, rickets patients 270U/L - 300U/L ( P < 0. 001). BALP level of the patients aged one year or over was higher, and as high as 270U/L( P <0.05. P <0.001). After Vitamin D3 treatment, BALP level of rickets patients decreased more rapidly than CP children (P < 0.001). Conclusion; CP patients had a bone calcification, and the younger the patients, or the more severe their deformity, the higher their BALP levels were.